Anti-oxidant, Anti-inflammatory, Astringent Activities and Skin Barrier Enhancement Effects of Cynomorium songaricum Extract

The present study investigates the effects of two extracts from <i>Cynomorium songaricum</i> (CS) on skin barrier enhancement and astringent activity. Although CS have been reported in various diseases including cancer, diabetes inflammatory diseases, protective are poorly understood. To test protection abilities, anti-oxidant anti-inflammatory activities radical scavenging activity, polyphenol contents measurement, nitric oxide (NO) production, iNOS protein level IL-6 cytokine were tested. <i>C. methanol extract (CSM) showed potent activities. CSM also enhanced activity a dose-dependent manner. In addition, anti-wrinkle tested using elastase inhibition rate, MMP-1, AQP-3 expressions. Furthermore, mRNA filaggrin, loricrin, involucrin was significantly increased treated cells, as compared with TNF-α cells. Therefore, may be source for cosmetics or treating diseases.